There are several causes of low testosterone, including obesity. These factors include insulin resistance, increased expression of the aromatase enzyme, and higher levels of estradiol. Some of these conditions can be managed by making dietary and behavioural changes. The best way to increase testosterone levels is to get more exercise. Anawalt recommends exercising for at least an hour a day, and breaking the exercise up into short 20-minute bouts. Strength training exercises can help build muscle.
Insulin resistance
- High insulin levels and obesity are both associated with lowered testosterone levels. Low testosterone levels can also contribute to inflammatory conditions, such as Alzheimer’s disease. The metabolic syndrome, which includes high insulin levels and diabetes, is a major risk factor for these diseases. Low testosterone levels can also result in impaired neural health.
- Although it is not known exactly why low testosterone occurs, there have been studies that have linked low testosterone levels and metabolic syndrome. The Laaksonen study and the MMAS study have both shown an association between low testosterone levels and metabolic syndrome. The Third National Health and Nutrition Survey analyzed data from nearly 4,000 men. They found that men with low testosterone levels were four times more likely to develop diabetes than those with normal levels. If you have serious ED problem then must try Kamagra 100mg sildenafil.
- Similarly, an increase in TNFa levels in adipose tissue is associated with low testosterone levels. This is because TNFa is an inhibitor of insulin receptor transduction in adipose tissue. Inflammatory markers such as IL-6 are also associated with low testosterone levels in males. Low testosterone levels are a leading cause of diabetes in men, with an estimated 30% to 50 percent of Type 2 diabetes resulting from low testosterone levels.
Higher estradiol promotion rate
- It has been suggested that high levels of estradiol in the body are associated with a reduced risk of dementia, particularly in women. However, the mechanism by which estradiol promotes brain function is unknown. Estradiol has been shown to have anti-inflammatory properties, which may contribute to the enhanced cognitive performance seen in women when estradiol is elevated. Moreover, it has been shown that estradiol promotes HPA activity, which may explain the association between estradiol levels and brain function.
- It is believed that the increase in obesity increases the production of estradiol. Although the release of estradiol from adipose tissue is regulated by the hypothalamic GnRH, the increased production of estradiol may inhibit gonadal testosterone production. Moreover, excess estradiol may interfere with the steroidogenesis of the Leydig cells.
Increased expression of aromatase enzyme
- Increasing expression of the aromatase enzyme in adipocytes leads to decreased testosterone in obese men. This enzyme is involved in the conversion of androstenedione and testosterone into estrogens. These estrogens inhibit the production of testosterone by the testis and exert negative feedback on the hypothalamus and pituitary gland. This causes hypogonadotropism. Fortunately, a solution to the problem exists: treatment.
- However, if men with obesity exhibit nonclassical hypogonadism, testosterone treatment may not be appropriate. Similarly, the use of AIs and SERMs should be limited to clinical trials. If you are looking for serious ED problem then must try Vidalista 80.
Diet and behavioural modifications
- Diet and behavioural modifications for obesity and men with low testosterone may not lead to sustained weight loss. New research from Gulf Medical University School of Medicine analyzed data from a German registry that tracked men with low testosterone over 15 years. The researchers compared data from 471 men who were obese and received long-term testosterone therapy with the same data from 276 men who were not on any type of testosterone therapy. The men receiving testosterone therapy lost an average of 13 pounds over a period of eight years. In contrast, the men in the control group gained 13 pounds over the same time period.
Type 2 diabetes
- In a recent study, researchers found that testosterone therapy can reverse Type 2 diabetes in one-third of men with the disease. This prospective registry-based study was conducted over 11 years in Bremerhaven, Germany, and published in the Journal of Diabetes, Obesity and Metabolism. Dandona presented the study’s results at the Mohan Diabetes Foundation Symposium in Chennai, India, where he received the prestigious Life Achievement Award.
- The researchers found that men with Type 2 diabetes had significantly lower testosterone levels than men without the disease. The difference was -76.6 ng/dL. However, men with higher testosterone levels were at a 42% lower risk of developing Type 2 diabetes.
